Active properties of hippocampal CA3 pyramidal neuron dendrites (Record no. 340550)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02257ntm a22003017a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | AT-ISTA |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20230705141734.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160531s2012 au ||||| m||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | IST |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Kim, Sooyun |
| 9 (RLIN) | 2636 |
| 245 ## - TITLE STATEMENT | |
| Title | Active properties of hippocampal CA3 pyramidal neuron dendrites |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Name of publisher, distributor, etc. | IST Austria |
| Date of publication, distribution, etc. | 2012 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Accompanying material | DVD included (Videos of Patching CA3 Dendrites) |
| 500 ## - GENERAL NOTE | |
| General note | Thesis |
| 505 ## - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Publication List |
| 505 ## - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Abstract |
| 505 ## - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 1 Introduction |
| 505 ## - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 2 Materials and Methods |
| 505 ## - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 3 Results |
| 505 ## - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 4 Discussion |
| 505 ## - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 5 List of Abbreviations |
| 505 ## - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 6 References |
| 505 ## - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 7 Curriculum Vitae |
| 505 ## - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 8 Acknowledgments |
| 505 ## - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 9 Appendix |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | CA3 pyramidal neurons are important for memory formation and pattern completion in the hippocampal network. These neurons receive multiple excitatory inputs from numerous sources. Therefore, the rules of spatiotemporal integration of multiple synaptic inputs and propagation of action potentials are important to understand how CA3 neurons contribute to higher brain functions at cellular level. By using confocally targeted patch-clamp recording techniques, we investigated the biophysical properties of rat CA3 pyramidal neuron dendrites. We found two distinct dendritic domains critical for action potential initiation and propagation: In the proximal domain, action potentials initiated in the axon backpropagate actively with large amplitude and fast time course. In the distal domain, Na+-channel mediated dendritic spikes are efficiently evoked by local dendritic depolarization or waveforms mimicking synaptic events. These findings can be explained by a high Na+-to-K+ conductance density ratio of CA3 pyramidal neuron dendrites. The results challenge the prevailing view that proximal mossy fiber inputs activate CA3 pyramidal neurons more efficiently than distal perforant inputs by showing that the distal synapses trigger a different form of activity represented by dendritic spikes. The high probability of dendritic spike initiation in the distal area may enhance the computational power of CA3 pyramidal neurons in the hippocampal network. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Materials specified (bound volume or other part) | Damaged status | Not for loan | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Not Lost | Dewey Decimal Classification | DVD included on back cover | Library | Library | 31/05/2016 | Quiet Room | AT-ISTA#001146 | 15/09/2025 | 31/05/2016 | Book |