MARC details
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06795cam a2200673Ii 4500 |
| 001 - CONTROL NUMBER |
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ocn830162414 |
| 003 - CONTROL NUMBER IDENTIFIER |
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OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20240925154536.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
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m d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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130316t20132013si a ob 001 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EBLCP |
| Language of cataloging |
eng |
| Description conventions |
rda |
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pn |
| Transcribing agency |
EBLCP |
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OCLCO |
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YDXCP |
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MHW |
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OHS |
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OCLCO |
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N$T |
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E7B |
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OCLCA |
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OCLCF |
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UKDOC |
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OCLCQ |
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NLGGC |
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OCLCQ |
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OCLCQ |
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AGLDB |
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OCLCO |
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OCLCO |
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OCLCO |
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AJS |
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OCLCO |
| 066 ## - CHARACTER SETS PRESENT |
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| Alternate G0 or G1 character set |
(S |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9781848167551 |
| Qualifying information |
(electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
1848167555 |
| Qualifying information |
(electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| Canceled/invalid ISBN |
9781848167544 |
| Qualifying information |
(cloth) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| Canceled/invalid ISBN |
1848167547 |
| Qualifying information |
(cloth) |
| 035 ## - SYSTEM CONTROL NUMBER |
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| System control number |
545493 |
| -- |
(N$T) |
| 035 ## - SYSTEM CONTROL NUMBER |
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| System control number |
(OCoLC)830162414 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
RC523 |
| 060 #4 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
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| Classification number |
WT 155 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
HEA |
| Subject category code subdivision |
039140 |
| Source |
bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED |
| Subject category code subdivision |
056000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
616.831 |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
MAIN |
| 245 00 - TITLE STATEMENT |
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| Title |
Alzheimer's disease : |
| Remainder of title |
insights into low molecular weight and cytotoxic aggregates from in vitro and computer experiments - molecular basis of amyloid-beta protein aggregation and fibril formation / |
| Statement of responsibility, etc. |
Philippe Derreumaux, University of Paris 7, France, editor. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Singapore : |
| Name of producer, publisher, distributor, manufacturer |
World Scientific Publishing Company, |
| Date of production, publication, distribution, manufacture, or copyright notice |
[2013] |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Date of production, publication, distribution, manufacture, or copyright notice |
©2013 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
1 online resource (xix, 444 pages) : |
| Other physical details |
illustrations. |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 490 1# - SERIES STATEMENT |
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| Series statement |
Molecular Medicine and Medicinal Chemistry ; |
| Volume/sequential designation |
v. 7 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc |
Includes bibliographical references and index. |
| 588 ## - SOURCE OF DESCRIPTION NOTE |
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| Source of description note |
Description based on print version record. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Alzheimer's disease is the most common form of senile dementia, affecting more than 24 million people worldwide. It is characterised pathologically by abnormally high levels of neurofibrillary tangles resulting from the accumulation of tau protein in dead and dying neurons, and by elevated numbers of senile plaques in the cortex and hippocampus of the brain. The major component of senile plaques is a small protein of 39-43 amino acids called amyloid-? (A?). Thus far, no treatment has been shown to slow the progression of sporadic and familial Alzheimer's disease. A large body of evidence points. |
| 590 ## - LOCAL NOTE (RLIN) |
|---|
| Local note |
WorldCat record variable field(s) change: 650 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Alzheimer's disease |
| General subdivision |
Molecular aspects. |
| 9 (RLIN) |
80252 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Alzheimer's disease. |
| 9 (RLIN) |
86843 |
| 650 12 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Alzheimer Disease |
| 9 (RLIN) |
80242 |
| 650 #6 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Maladie d'Alzheimer |
| General subdivision |
Aspect moléculaire. |
| 9 (RLIN) |
1020710 |
| 650 #6 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Maladie d'Alzheimer. |
| 9 (RLIN) |
969985 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
HEALTH & FITNESS |
| General subdivision |
Diseases |
| -- |
Alzheimer's & Dementia. |
| Source of heading or term |
bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
MEDICAL |
| General subdivision |
Neurology. |
| Source of heading or term |
bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Alzheimer's disease |
| General subdivision |
Molecular aspects. |
| Source of heading or term |
fast |
| Authority record control number |
(OCoLC)fst00806550 |
| 9 (RLIN) |
80252 |
| 655 #0 - INDEX TERM--GENRE/FORM |
|---|
| Genre/form data or focus term |
Electronic books. |
| 9 (RLIN) |
396 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Derreumaux, Philippe, |
| Relator term |
editor. |
| 9 (RLIN) |
678584 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Print version: |
| Title |
Alzheimer's disease. |
| Place, publisher, and date of publication |
London : Imperial College Press, [2013] |
| International Standard Book Number |
9781848167544 |
| Record control number |
(DLC) 2013427093 |
| -- |
(OCoLC)829952915 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
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| Uniform title |
Molecular medicine and medicinal chemistry. |
| 9 (RLIN) |
583454 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Materials specified |
EBSCOhost |
| Uniform Resource Identifier |
<a href="https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=545493">https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=545493</a> |
| 880 0# - ALTERNATE GRAPHIC REPRESENTATION |
|---|
| Linkage |
505-00/(S |
| a |
Amyloid hypothesis: molecular and cellular aspects of toxicity / Rakez Kayed and Cristian A. Lasagna-Reeves -- Models of wild-type and disease-causing mutant β-amyloid fibrils. Insights from solid-state nuclear magnetic resonance spectroscopy / Stephen C. Meredith -- Biophysical characterization of Aβ assembly / Eric Y. Hayden and David B. Teplow -- Coordination of metal ions to β-amyloid peptide: impact on Alzheimer's disease / Peter Faller, Giovanni La Penna, Christelle Hureau and Sara Furlan -- Amyloidogenesis, neurogenesis, learning, and memory in Alzheimer's disease: lessons from transgenic mouse models / Laure Vennet and Claire Rampon -- Inhibitor design against cytotoxic β-amyloid species / Andrew J. Doig -- Kinetics of amyloid growth / Jessica Nasica-Labouze and Normand Mousseau -- Probing the stability of fibril and tubular species using all-atom molecular dynamics simulations in solution: insight into polymorphism / Yifat Miller, Buyong Ma and Ruth Nussinov -- Mechanisms of growth of β-amyloid fibrils and binding of non-steroidal anti-inflammatory drug ligands / Takako Takeda and Dmitri Klimov -- Exploring the structures of β-amyloid oligomers in aqueous solution using coarse-grained protein models / Yassmine Chebaro and Philippe Derreumaux -- Pathways of amyloid fibril formation using a simplified peptide model / Riccardo Pellarin -- From disordered amyloid β-proteins to soluble oligomers and protofibrils using discrete molecular dynamics / Mark Betnel, Nikolay V. Dokholyan and Brigita Urbanc -- Aβ proteins-lipid membrane interaction: computational simulation study / Yuguang Mu -- Molecular insights into the assembly of β-amyloid on surfaces and carbon nanotubes / Guanghong Wei, Yin Luo and Zhaoming Fu -- Inhibiting peptide and protein self-aggregation: what can simulations tell us? / Joan-Emma Shea and Giorgio Colombo. |
| 880 ## - ALTERNATE GRAPHIC REPRESENTATION |
|---|
| Linkage |
520-00/(S |
| a |
Alzheimer's disease is the most common form of senile dementia, affecting more than 24 million people worldwide. It is characterised pathologically by abnormally high levels of neurofibrillary tangles resulting from the accumulation of tau protein in dead and dying neurons, and by elevated numbers of senile plaques in the cortex and hippocampus of the brain. The major component of senile plaques is a small protein of 39-43 amino acids called amyloid-β (Aβ). Thus far, no treatment has been shown to slow the progression of sporadic and familial Alzheimer's disease.A large body of evidence points, however, to the early Aβ-formed oligomers as the primary toxic species in Alzheimer's disease. A powerful strategy for developing pharmaceutical treatments against Alzheimer's is to elucidate the pathways of oligomer formation and determine the structures of the toxic aggregates.This book provides a panoramic view across recent in vitro and in vivo studies along with state-of-the-art computer simulations, designed to increase the readers' understanding of Aβ oligomerisation and fibril formation. At the same time, the book delves into the pathogenesis of familial and sporadic Alzheimer's disease at the atomic level of detail.Written by leading authors in their respective fields, this book will be valuable to all scientists working on Alzheimer's disease. |
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123Library |
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123L |
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114830 |
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ProQuest Ebook Central |
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EBLB |
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EBL1143306 |
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ebrary |
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EBRY |
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ebr10674347 |
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EBSCOhost |
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EBSC |
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545493 |
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YBP Library Services |
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YANK |
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10258425 |
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92 |
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N$T |