Programmed cell death. Part B, The biology and therapeutic implications of cell death / edited by Roya Khosravi-Far, Zahra Zakeri, Richard A. Lockshin, Mauro Piacentini.

Contributor(s):

Material type: Text

TextSeries: Methods in enzymology ; v. 446.Publication details: San Diego, California : Academic Press/Elsevier, ©2008.Description: 1 online resource (xlviii, 450 pages, 6 unnumbered pages of plates) : illustrationsContent type:

text

Media type:

computer

Carrier type:

online resource

ISBN:

9780080888132
0080888135
0123744644
9780123744647

Other title:

Biology and therapeutic implications of cell death

Subject(s): Genre/Form:

Additional physical formats: Print version:: Programmed cell death. Part B, The biology and therapeutic implications of cell death.DDC classification:

571.936 22

LOC classification:

QH671 .M49 v.446eb

NLM classification:

W1
QU 375

Online resources:

Click here to access online

Contents:

Analysis of autographic and necrotic cell death in Dictyostelium / C. Giusti... [at al.]. -- Methods and protocols for studying cell death in Drosophila / D. Denton, K. Mills, S. Kumar. -- In Vivo and In Vitro methods for studying apoptotic cell engulfment in Drosophia / E.A. Silva, J. Burden, N.C. Franc. -- A mouse mammary epithelial cell model to identify molecular mechanisms regulating breast cancer progression / V. Karantza-Wadsworth, E. White. -- Immortalized mouse epithelial cell models to study the role of apoptosis in cancer / R. Matthew... [et al.]. -- DNA damage response and apoptosis / D. Plesca, S. Muzumder, A. Almason. -- Phorbol ester-induced apoptosis and senescene in cancel cell models / L. Xiao... [et al.]. -- Manipulation of PKC isozymes by RNA interference and inducible expression of OKC constructs / A. Basu, S.D. Persaud, U. Sivaprasad. -- Studying p53-dependent cell death In Vitro and In Vivo / K. Kuribayashi, N. Finnberg, W.S. El-Deiry. -- NF-kB as a determinant of distinct dell death pathways / I.L. Chʼen, S.M. Hedrick, A. Hoffmann. -- Purification and bioassay of hedgehog ligans for the study of cell dealth and survival / P. Martinez-Chinchilla, N.A. Riobo. -- Experimental approaches to investiage the proteasomal degradation pathways involved in regulaiton of apoptosis / A. Tseng... [et al.]. -- Ubiquitination mediated by inhibitor of apoptosis proteins / Sun-Mi. Park... [et al.]. -- Phosphatases and regulation of cell death / Chi-Wu Chiang, L. Yan, E. Yang. -- Analysis of neuronal cell death in mammals / M. D'Amelio... [et al.]. -- Diissecting apoptosis and intrinsic death pathways in the heart / D. Weidman...[et al.]. -- Quantification of vascular endothelial cell apoptosis In Vivo / X. Zhang, S. Parangi. -- Recombinant TRAIL and TRAIL receptor analysis / N. Harper, M. MacFarlane. -- Analysis of Tnf-related apoptosis-inducing ligand In Vivo through bone marrow transduction and transplantation / K. Song, R. Mariappan, R. Khosravi-Far. -- Overcoming resistance to TRAIL-induced apoptosis in prostate cancer by regulation of c-Flip / X. Zhang, W. Li. A.F. Olumi. -- Caspase assays: identifying caspase activity and substrates In Vitro and In Vivo / C. Pop, G.S. Salvesen, F.L. Scott. -- Synthesis and biophysical characterization of staiblized ₍-Helices of BCL-2 domains / G. H. Bird... [et al.]. -- Dissection of the BCL-2 family signaling network with stabilized ₍-Helices of BCL-2 domains / K. Pitter... [et al.]. -- ERM-mediated genetic screens in mammalian cells / D. Liu, Z. Songyang

Summary: One of the major goals of researchers in the field of apoptosis is to identify targets for novel therapies in cancer, AIDS, and Alzheimer's disease. Understanding the molecular mechanisms of the various components of the apoptotic pathways is the first step to reaching this goal. The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner (United Kingdom), H. Robert Horvitz (US) and John E. Sulston (UK) "for their discoveries concerning genetic regulation of organ development and programmed cell death." Cell death is a fundamental aspect of embryonic development, normal cellular turnover and maintenance of homeostasis (maintaining a stable, constant environment) on the one hand, and aging and disease on the other. This volume addresses the significant advances with the techniques that are being used to analyze cell death. * This volume provides the necessary, trusted methods to carry out this research on these latest therapeutic techniques. Once researchers understand the molecular mechanisms of the apoptotic pathways, they can begin to develop new therapies. * Presents key methods on studying tumors and how these cancer cells evade cell death. * Eliminates searching through many different sources to avoid pitfalls so the same mistakes are not made over and over.

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Item type	Current library	Collection	Call number	Status	Date due	Barcode	Item holds
eBook	e-Library	eBook Elsevier		Available

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Includes bibliographical references and indexes.

Print version record.

One of the major goals of researchers in the field of apoptosis is to identify targets for novel therapies in cancer, AIDS, and Alzheimer's disease. Understanding the molecular mechanisms of the various components of the apoptotic pathways is the first step to reaching this goal. The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner (United Kingdom), H. Robert Horvitz (US) and John E. Sulston (UK) "for their discoveries concerning genetic regulation of organ development and programmed cell death." Cell death is a fundamental aspect of embryonic development, normal cellular turnover and maintenance of homeostasis (maintaining a stable, constant environment) on the one hand, and aging and disease on the other. This volume addresses the significant advances with the techniques that are being used to analyze cell death. * This volume provides the necessary, trusted methods to carry out this research on these latest therapeutic techniques. Once researchers understand the molecular mechanisms of the apoptotic pathways, they can begin to develop new therapies. * Presents key methods on studying tumors and how these cancer cells evade cell death. * Eliminates searching through many different sources to avoid pitfalls so the same mistakes are not made over and over.

English.

880-01 Analysis of autographic and necrotic cell death in Dictyostelium / C. Giusti... [at al.]. -- Methods and protocols for studying cell death in Drosophila / D. Denton, K. Mills, S. Kumar. -- In Vivo and In Vitro methods for studying apoptotic cell engulfment in Drosophia / E.A. Silva, J. Burden, N.C. Franc. -- A mouse mammary epithelial cell model to identify molecular mechanisms regulating breast cancer progression / V. Karantza-Wadsworth, E. White. -- Immortalized mouse epithelial cell models to study the role of apoptosis in cancer / R. Matthew... [et al.]. -- DNA damage response and apoptosis / D. Plesca, S. Muzumder, A. Almason. -- Phorbol ester-induced apoptosis and senescene in cancel cell models / L. Xiao... [et al.]. -- Manipulation of PKC isozymes by RNA interference and inducible expression of OKC constructs / A. Basu, S.D. Persaud, U. Sivaprasad. -- Studying p53-dependent cell death In Vitro and In Vivo / K. Kuribayashi, N. Finnberg, W.S. El-Deiry. -- NF-kB as a determinant of distinct dell death pathways / I.L. Chʼen, S.M. Hedrick, A. Hoffmann. -- Purification and bioassay of hedgehog ligans for the study of cell dealth and survival / P. Martinez-Chinchilla, N.A. Riobo. -- Experimental approaches to investiage the proteasomal degradation pathways involved in regulaiton of apoptosis / A. Tseng... [et al.]. -- Ubiquitination mediated by inhibitor of apoptosis proteins / Sun-Mi. Park... [et al.]. -- Phosphatases and regulation of cell death / Chi-Wu Chiang, L. Yan, E. Yang. -- Analysis of neuronal cell death in mammals / M. D'Amelio... [et al.]. -- Diissecting apoptosis and intrinsic death pathways in the heart / D. Weidman...[et al.]. -- Quantification of vascular endothelial cell apoptosis In Vivo / X. Zhang, S. Parangi. -- Recombinant TRAIL and TRAIL receptor analysis / N. Harper, M. MacFarlane. -- Analysis of Tnf-related apoptosis-inducing ligand In Vivo through bone marrow transduction and transplantation / K. Song, R. Mariappan, R. Khosravi-Far. -- Overcoming resistance to TRAIL-induced apoptosis in prostate cancer by regulation of c-Flip / X. Zhang, W. Li. A.F. Olumi. -- Caspase assays: identifying caspase activity and substrates In Vitro and In Vivo / C. Pop, G.S. Salvesen, F.L. Scott. -- Synthesis and biophysical characterization of staiblized ₍-Helices of BCL-2 domains / G. H. Bird... [et al.]. -- Dissection of the BCL-2 family signaling network with stabilized ₍-Helices of BCL-2 domains / K. Pitter... [et al.]. -- ERM-mediated genetic screens in mammalian cells / D. Liu, Z. Songyang