TY  - BOOK
AU  - Manfredi,Giovanni
AU  - Kawamata,Hibiki
TI  - Neurodegeneration: methods and protocols 
T2  - Methods in molecular biology,
SN  - 9781617793288
AV  - RC394.D35 N48 2011
U1  - 616.8 23
PY  - 2011///
CY  - New York
PB  - Humana Press
KW  - Nervous system
KW  - Degeneration
KW  - Laboratory manuals
KW  - Neurons
KW  - Research
KW  - Methodology
KW  - Molecular neurobiology
KW  - Animals
KW  - Diseases
KW  - Biological models
KW  - Cultures (Biology)
KW  - Medical laboratory technology
KW  - Mathematical models
KW  - Animal models
KW  - Animal Diseases
KW  - Models, Animal
KW  - Nervous System Diseases
KW  - Models, Biological
KW  - Culture Techniques
KW  - Pathologic Processes
KW  - Disease
KW  - Clinical Laboratory Techniques
KW  - Investigative Techniques
KW  - Pathological Conditions, Signs and Symptoms
KW  - Models, Theoretical
KW  - Analytical, Diagnostic and Therapeutic Techniques and Equipment
KW  - Disease Models, Animal
KW  - Cell Culture Techniques
KW  - Nerve Degeneration
KW  - Neurodegenerative Diseases
KW  - Neurones
KW  - Recherche
KW  - Méthodologie
KW  - Neurobiologie moléculaire
KW  - Animaux
KW  - Maladies
KW  - Système nerveux
KW  - Modèles biologiques
KW  - Cultures (Biologie)
KW  - Médecine
KW  - Laboratoires
KW  - Technique
KW  - Modèles mathématiques
KW  - Modèles animaux
KW  - Cellules
KW  - Culture
KW  - Nerfs
KW  - Dégénérescence
KW  - illness
KW  - aat
KW  - disease
KW  - mathematical models
KW  - fast
KW  - biomedische wetenschappen
KW  - biomedicine
KW  - neurowetenschap
KW  - neuroscience
KW  - Medicine (General)
KW  - Geneeskunde (algemeen)
KW  - Laboratory Manual
KW  - lcgft
KW  - Manuels de laboratoire
KW  - rvmgf
N1  - Includes bibliographical references and index; Introduction to neurodegenerative diseases and related techniques -- In vivo and in vitro determination of cell death markers in neurons -- Degenerating processes identified by electron microscopic immunocytochemical methods -- Isolation and culture of neurons and astrocytes from the mouse brain cortex -- Isolation and culture of postnatal spinal motoneurons -- Converting human pluripotent stem cells to neural tissue and neurons to model neurodegeneration -- Neural differentiation of induced pluripotent stem cells -- Developing yeast models of human neurodegenerative disorders -- Modeling dopamine neuron degeneration in Caenorhabditis elegans -- Role of the proteasome in fly models of neurodegeneration -- Modeling neurodegenerative diseases in zebrafish embryos -- Practical considerations of genetic rodent models for neurodegenerative diseases -- Modeling focal cerebral ischemia in vivo -- Pharmacological models of Parkinson's disease in rodents
N2  - Neurodegenerative disorders, such as Alzheimer's and Parkinson's disease are a growing burden on our society. Understanding and treating these common diseases is one of the major current challenges for the biomedical field. In Neurodegeneration: Methods and Protocols, experts in the field tackle this challenge and present cutting-edge analytical and technological approaches to study the mechanisms underlying neurodegenerative processes. Organizes into five sections, chapters detail protocols for isolating and culturing cells from the nervous system, production and use of animal models, characterization of cell death, analytical tools to study disease mechanisms, and therapeutic approaches for neurodegeneration. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Neurodegeneration: Methods and Protocols serves as an ideal guide to both novice and professional researchers in the field of neurodegeneration
UR  - https://link-springer-com.libraryproxy.ist.ac.at/10.1007/978-1-61779-328-8
ER  -