TY - BOOK AU - Hopwood,D.A. TI - Complex enzymes in microbial natural product biosynthesis T2 - Methods in enzymology, SN - 9780080923369 AV - QP601 .M49 vol.459eb U1 - 572.45 22 PY - 2009/// CY - Amsterdam, Boston PB - Elsevier/Academic Press KW - Biosynthesis KW - Polyketides KW - Synthesis KW - Peptides KW - Carbohydrates KW - Biological Products KW - biosynthesis KW - Enzymes KW - Peptide Biosynthesis KW - Polyketide Synthases KW - Biosynthèse KW - Acétogénines KW - Synthèse KW - Glucides KW - SCIENCE KW - Life Sciences KW - Biochemistry KW - bisacsh KW - fast KW - natuurlijke producten KW - natural products KW - biosynthese KW - acetogeninen KW - acetogenins KW - cumarinen KW - coumarins KW - Biochemie KW - Electronic books N1 - Includes bibliographical references and indexes; Introduction to polyketide biosynthesis / K.J. Weissman -- Structural enzymology of polyketide synthases / S.C. Tsai and B.D. Ames -- Fungal type I polyketide synthases / R.J. Cox and T.J. Simpson -- Tandem acyl carrier protein domains in polyunsaturated fatty acid synthases / H. Jiang, S.R. Rajski and B. Shen -- Iterative type I polyketide synthases for enediyne core biosynthesis / G.P. Horsman, S.G. Van Lanen and B. Shen -- The DEBS paradigm for type I modular polyketide synthases and beyond / L. Katz -- Formation and characterization of acyl carrier protein-linked polyketide synthase extender units / Y.A. Chan and M.G. Thomas -- Type I polyketide synthases that require discrete acyltransferases / Y.Q. Cheng [and others] -- The enzymology of polyether biosynthesis / T. Liu, D.E. Cane and Z. Deng -- Enzymology of the polyenes pimaricin and candicidin biosynthesis / J.F. Martin and J.F. Aparicio -- Genetic analysis of nystatin and amphotericin biosynthesis / S. Zotchev and P. Caffrey -- Polyketide versatility in the biosynthesis of complex mycobacterial cell wall lipids / T. Chopra and R.S. Gokhale -- Genetic engineering to produce polyketide analogues / C.D. Reeves and E. Rodriguez -- Design and synthesis of pathway genes for polyketide biosynthesis / S. Peiru, H. Gramajo and H.G. Menzella -- Heterologous production of polyketides in bacteria / E. Rodriguez, H.G. Menzella and H. Gramajo -- In vitro analysis of type II polyketide synthase / W. Zhang and Y. Tang -- Bacterial fatty acid synthesis and its relationships with polyketide synthetic pathways / J.E. Cronan and J. Thomas -- Aminocoumarins mutasynthesis, chemoenzymatic synthesis, and metabolic engineering / L. Heide -- Enzymology of aminoglycoside biosynthesis-deduction from gene clusters / U.F. Wehmeier and W. Piepersberg -- Biosynthetic enzymes for the aminoglycosides butirosin and neomycin / F. Kudo and T. Eguchi -- Enzymatic synthesis of TDP-deoxysugars / J. White-Phillip, C.J. Thibodeaux and H.W. Liu N2 - This volume will showcase the most important chemical classes of complex enzymes, which have been an important traditional source of valuable antibiotics and other drugs UR - https://www-sciencedirect-com.libraryproxy.ist.ac.at/science/bookseries/00766879/459 ER -