TY  - BOOK
AU  - Corasolla Carregari,Victor
TI  - Understanding PTMs in Neurodegenerative Diseases
T2  - Advances in Experimental Medicine and Biology Series
SN  - 9783031054600
U1  - 616.80471 
PY  - 2022///
CY  - Cham
PB  - Springer International Publishing AG
KW  - Metabolism
KW  - Nervous system-Degeneration
KW  - Proteomics
N1  - Description based on publisher supplied metadata and other sources
N2  - Intro -- Preface -- Contents -- Chapter 1: Protein Extraction and Sample Preparation Methods for Shotgun Proteomics with Central Nervous System Cells and Brain Tissue -- 1.1 Introduction -- 1.2 Lysis Buffers -- 1.3 Buffer Compositions, Pros, and Cons -- 1.3.1 RIPA Buffer -- 1.3.2 Modified RIPA Buffer -- 1.3.3 SDS Sample Buffer -- 1.3.4 NP-40 Lysis Buffer -- 1.3.5 HEPES Lysis Buffer -- 1.3.6 CHAPS Lysis Buffer -- 1.3.7 Urea Buffer -- 1.3.8 Protease Inhibitor Cocktail -- 1.4 Sample Preparation Methods -- 1.4.1 Central Nervous System (CNS) Cells -- 1.4.2 Postmortem Brain Tissue -- 1.4.3 Cerebrospinal Fluid (CSF) -- 1.5 Digestion Methods for Shotgun Proteomics -- 1.5.1 In-Solution Digestion -- 1.5.2 Homemade C18 Microcolumn -- 1.5.3 Filter-Aided Sample Preparation (FASP) -- 1.5.4 Suspension Trap (S-TRAP) -- 1.6 Conclusions -- References -- Chapter 2: Phosphopeptide Enrichment Techniques: A Pivotal Step for Phosphoproteomic Studies -- 2.1 Introduction -- 2.2 Phosphopeptide Enrichment -- 2.3 IMAC -- 2.4 TiO2 -- 2.5 TiO2 Micro-Column -- 2.6 SIMAC -- 2.7 Conclusion -- References -- Chapter 3: Post-Translational Modifications During Brain Development -- 3.1 Biological Steps of Neurodevelopment and Post-translational Modifications -- 3.2 Post-translational Modifications During Neurodevelopment -- 3.2.1 Cytoskeletal Proteins -- 3.2.2 Gene Transcription and Protein Translation -- 3.2.3 Signaling Pathways -- 3.3 Concluding Remarks -- References -- Chapter 4: Aberrant Protein Glycosylation in Brain Cancers, with Emphasis on Glioblastoma -- 4.1 Introduction -- 4.2 Asparagine N-Linked Glycosylation Family (ALG) -- 4.3 β-1,4-Galactosyltransferase (B4T) and β-1,3-Nacetylglucosaminyltransferase (B3T) Families -- 4.4 Fucosyltransferase Family (FUT) -- 4.5 N-Acetylgalactosaminyltransferase Family (GALNT) -- 4.6 Hexosaminidase Family (HEX)
ER  -