TY  - BOOK
AU  - Benet,Leslie Z.
AU  - Donaldson,Molla S.
ED  - Institute of Medicine (U.S.).
ED  - Institute of Medicine (U.S.).
TI  - Clinical applications of mifepristone (RU 486) and other antiprogestins: assessing the science and recommending a research agenda 
SN  - 0585024782
AV  - RG137.6.M53 C57 1993eb
U1  - 615/.766 20
PY  - 1993///
CY  - Washington, D.C.
PB  - National Academy Press
KW  - Mifepristone
KW  - Research
KW  - Abortifacients
KW  - Progesterone
KW  - Antagonists
KW  - Abortifacient Agents
KW  - antagonists & inhibitors
KW  - Mifépristone
KW  - Recherche
KW  - Abortifs
KW  - Antiprogestérones
KW  - MEDICAL
KW  - Pharmacology
KW  - bisacsh
KW  - fast
KW  - RU 486
KW  - gnd
N1  - "Support for this project was provided by a grant from the Henry J. Kaiser Family Foundation, Menlo Park, California."--Title page verso; Committee chairman: Leslie Z. Benet; Includes bibliographical references and index; Background and historical perspectives -- IOM report -- Cross-cutting recommendations -- Uses of antiprogestins: the reproductive cycle -- Contraception -- Post-coital contraception -- Menses induction -- Uses of antiprogestins: the reproductive cycle -- Pregnancy termination during the first trimester -- Pregnancy termination during the second trimester -- Cervical ripening -- Labor induction in late pregnancy -- Other therapeutic uses of antiprogestins -- Endometriosis -- Uterine leiomyomas (fibroids) -- Breast cancer -- Meningiomas -- Antiglucocorticoid effects of antiprogestins -- Glucocorticoid function -- Therapeutic use of mifepristone (RU 486) as an antiglucocorticoid -- Adverse antiglucocorticoid effects of antiprogestins -- Animals as models for studying antiprogestins -- Agenda for the IOM workshop "Antiprogestins: Assessing the Science" -- Background papers and presentations (in order of presentation at IOM workshop) -- 1993: RU 486: a decade on today and tomorrow / Etienne-Emile Baulieu; (cont) Overview and background: mechanism of action of antiprogestins / Nancy L. Weigel -- Use of antiprogestins in the reproductive cycle / Lynnette Kaye Nieman -- Potential contraceptive effects of antigestogens / David T. Baird -- Use of antiprogestins before 63 days of amenorrhea / Marc Bygdeman -- Uses of antiprogestins after 63 days of amenorrhea / Ancre Ulmann and Louise Silvestre -- Comments on session II -- David Grimes -- Use of antiprogestins in the management of endometriosis and leiomyoma / Samuel S.C. Yen -- Antiprogestins and the treatment of breast cancer / Kathryn B. Horwitz -- Uses of RU 486 as an antiglucocorticoid / Lynnette Kaye Nieman -- Primate models for the study of antiprogestins in reproductive medicine / Gary D. Hodgen -- Antiprogestogens: perspectives from a global research program / P.F.A. Van Look and H. von Hertzen -- Observers at the workshop on antiprogestins
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