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Retroviral proteases / edited by Lawrence C. Kuo, Jules A. Shafer.

Contributor(s): Material type: TextTextSeries: Methods in enzymology ; v. 241.Publication details: San Diego : Academic Press, ©1994.Description: 1 online resource (xxv, 432 pages, 10 unnumbered pages of plates) : illustrationsContent type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 0121821420
  • 9780121821425
Subject(s): Genre/Form: Additional physical formats: Print version:: Retroviral proteases.DDC classification:
  • 547.758 20
LOC classification:
  • QP601 M49 vol. 241
  • QP609.P78
NLM classification:
  • W1
  • QU 136
Other classification:
  • 42.32
  • WC 4355
  • BIO 303f
  • CHE 820f
  • CHE 832f
  • CHE 860f
  • CHE 810f
Online resources:
Contents:
1. Expression Systems for Retroviral Proteases / Jeffrey Stebbins and Christine Debouck -- 2. Genetic Approaches Designed to Minimize Cytotoxicity of Retroviral Protease / C.J. Rizzo and B.D. Korant -- 3. Host Strain Selection for Bacterial Expression of Toxic Proteins / Elizabeth Chen -- 4. Assay Methods for Retroviral Proteases / Christopher U.T. Hellen -- 5. Analysis of Human Immunodeficiency Virus Type 1 Protease Activity in Eukaryotic and Bacterial Cells / Andrew H. Kaplan, Marianne Manchester, Lorraine Everitt and Ronald Swanstrom -- 6. Synthetic Approaches to Continuous Assays of Retroviral Proteases / Grant A. Krafft and Gary T. Wang -- 7. Identification, Purification, and Cell Culture Assays of Retroviral Proteases / Klaus von der Helm, Sigrio Seelmeier, Alexei Kisselev and Hans Nitschko -- 8. Stability of Dimeric Retroviral Proteases / Paul L. Darke.
9. Use of Steady State Kinetic Methods to Elucidate the Kinetic and Chemical Mechanisms of Retroviral Proteases / Thomas D. Meek, Evelyn J. Rodriguez and Thelma S. Angeles -- 10. X-Ray Structures of Retroviral Proteases and Their Inhibitor-Bound Complexes / Dagmar Ringe -- 11. Probing Structure-Function Relationships in Human Immunodeficiency Virus Type 1 Protease via Molecular Dynamics Simulation / William E. Harte, Jr. and David L. Beveridge -- 12. Relationships of Human Immunodeficiency Virus Protease with Eukaryotic Aspartic Proteases / Xin-Li Lin, Ying-Zhang Lin and Jordan Tang -- 13. Processing of Retroviral Gag Polyproteins: An in Vitro Approach / Carol Carter and Gabriele Zybarth -- 14. Subsite Preferences of Retroviral Proteinases / Ben M. Dunn, Alla Gustchina, Alexander Wlodawer and John Kay -- 15. Specificity of Retroviral Proteases: An Analysis of Viral and Nonviral Protein Substrates / Alfredo G. Tomasselli and Robert L. Heinrikson.
16. Rapid Determination of Endoprotease Specificity Using Peptide Mixtures and Edman Degradation Analysis / Frank R. Masiarz and Bruce A. Malcolm -- 17. Design of Tight-Binding Human Immunodeficiency Virus Type 1 Protease Inhibitors / Joseph P. Vacca -- 18. Design of Symmetry-Based, Peptidomimetic Inhibitors of Human Immunodeficiency Virus Protease / Dale J. Kempf -- 19. Advances in Automated Docking Applied to Human Immunodeficiency Virus Type 1 Protease / Michael D. Miller, Robert P. Sheridan, Simon K. Kearsley and Dennis J. Underwood -- 20. Use of Molecular Dynamics and Free Energy Perturbation Calculations in Anti-Human Immunodeficiency Virus Drug Design / Margaret A. McCarrick and Peter Kollman -- 21. Qualitative Study of Drug Resistance in Retroviral Protease Using Structural Modeling and Site-Directed Mutagenesis / J. Chris Culberson, Bruce L. Bush and Vinod V. Sardana.
Action note:
  • digitized 2011 HathiTrust Digital Library committed to preserve
Summary: Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.
Holdings
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eBook eBook e-Library eBook Elsevier Available
Total holds: 0

Includes bibliographical references and indexes.

Print version record.

Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.

1. Expression Systems for Retroviral Proteases / Jeffrey Stebbins and Christine Debouck -- 2. Genetic Approaches Designed to Minimize Cytotoxicity of Retroviral Protease / C.J. Rizzo and B.D. Korant -- 3. Host Strain Selection for Bacterial Expression of Toxic Proteins / Elizabeth Chen -- 4. Assay Methods for Retroviral Proteases / Christopher U.T. Hellen -- 5. Analysis of Human Immunodeficiency Virus Type 1 Protease Activity in Eukaryotic and Bacterial Cells / Andrew H. Kaplan, Marianne Manchester, Lorraine Everitt and Ronald Swanstrom -- 6. Synthetic Approaches to Continuous Assays of Retroviral Proteases / Grant A. Krafft and Gary T. Wang -- 7. Identification, Purification, and Cell Culture Assays of Retroviral Proteases / Klaus von der Helm, Sigrio Seelmeier, Alexei Kisselev and Hans Nitschko -- 8. Stability of Dimeric Retroviral Proteases / Paul L. Darke.

9. Use of Steady State Kinetic Methods to Elucidate the Kinetic and Chemical Mechanisms of Retroviral Proteases / Thomas D. Meek, Evelyn J. Rodriguez and Thelma S. Angeles -- 10. X-Ray Structures of Retroviral Proteases and Their Inhibitor-Bound Complexes / Dagmar Ringe -- 11. Probing Structure-Function Relationships in Human Immunodeficiency Virus Type 1 Protease via Molecular Dynamics Simulation / William E. Harte, Jr. and David L. Beveridge -- 12. Relationships of Human Immunodeficiency Virus Protease with Eukaryotic Aspartic Proteases / Xin-Li Lin, Ying-Zhang Lin and Jordan Tang -- 13. Processing of Retroviral Gag Polyproteins: An in Vitro Approach / Carol Carter and Gabriele Zybarth -- 14. Subsite Preferences of Retroviral Proteinases / Ben M. Dunn, Alla Gustchina, Alexander Wlodawer and John Kay -- 15. Specificity of Retroviral Proteases: An Analysis of Viral and Nonviral Protein Substrates / Alfredo G. Tomasselli and Robert L. Heinrikson.

16. Rapid Determination of Endoprotease Specificity Using Peptide Mixtures and Edman Degradation Analysis / Frank R. Masiarz and Bruce A. Malcolm -- 17. Design of Tight-Binding Human Immunodeficiency Virus Type 1 Protease Inhibitors / Joseph P. Vacca -- 18. Design of Symmetry-Based, Peptidomimetic Inhibitors of Human Immunodeficiency Virus Protease / Dale J. Kempf -- 19. Advances in Automated Docking Applied to Human Immunodeficiency Virus Type 1 Protease / Michael D. Miller, Robert P. Sheridan, Simon K. Kearsley and Dennis J. Underwood -- 20. Use of Molecular Dynamics and Free Energy Perturbation Calculations in Anti-Human Immunodeficiency Virus Drug Design / Margaret A. McCarrick and Peter Kollman -- 21. Qualitative Study of Drug Resistance in Retroviral Protease Using Structural Modeling and Site-Directed Mutagenesis / J. Chris Culberson, Bruce L. Bush and Vinod V. Sardana.

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