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High throughput screening : methods and protocols.

Contributor(s): Material type: TextTextSeries: Springer protocols (Series) | Methods in molecular biology (Clifton, N.J.) ; v. 565.Publication details: Dordrecht ; New York : Humana Press, ©2009.Edition: 2nd ed. / edited by William P. Janzen and Paul BernasconiDescription: 1 online resource (xii, 268 pages : illustrations (some color))Content type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9781603272582
  • 1603272585
Subject(s): Genre/Form: Additional physical formats: Print version:: High throughput screening.DDC classification:
  • 660.6 23
LOC classification:
  • RS419.5 .H54 2009
NLM classification:
  • W1
  • QV 771
Other classification:
  • WC 4150
Online resources:
Contents:
Design and implementation of high-throughput screening assays / R. Macarrón and R.P. Hertzberg -- Creation of a small high-throughput screening facility / T. Flak -- Informatics in compound library management / M. Warne and L. Pemberton -- Statistics and decision making in high-throughput screening / I. Coma, J. Herranz and J. Martin -- Enzyme assay design for high-throughput screening / K.P. Williams and J.E. Scott -- Application of fluorescence polarization in HTS assays / X. Huang and A. Aulabaugh -- Screening G protein-coupled receptors: Measurement of intracellular calcium using the fluorometric imaging plate reader / R. Emkey and N.B. Rankl -- High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer / O.J. Trask [and others] -- Recent advances in electrophysiology-based screening technology and the impact upon ion channel discovery research / A. Southan and G. Clark -- Automated patch clamping using the QPatch / K.A. Jones [and others] -- High-throughput screening of the cyclic amp-dependent protein kinase (PKA) using the caliper microfluidic platform / L.J. Blackwell [and others] -- Use of primary human cells in high-throughput screens / A. Dunne, M. Jowett and S. Rees.
Action note:
  • digitized 2010 HathiTrust Digital Library committed to preserve
Summary: In the years since the release of the popular first edition, the field of High Throughput Screening (HTS) has evolved considerably, from a small niche area of study to a major, essential scientific technique. In High Throughput Screening: Methods and Protocols, Second Edition, experts in the field fully update the previous edition to best serve as an introduction to HTS for scientists who are just entering the field, and as a provider of key, significant detail so as to be useful to scientists in established HTS operations. Featuring new screening technologies as well as many well established methods, chapters offer comprehensive treatment of the activities directly related to HTS, such as compound library management, data handling, and robotics. As a volume in the highly successful Methods in Molecular Biology™ series, this work provides the kind of meticulous description and implementation advice that is crucial for getting optimal results. Authoritative and intrinsically practical, High Throughput Screening: Methods and Protocols, Second Edition promises to share the highest knowledge and enthusiasm with all those who use this versatile technology in their own labs.
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Includes bibliographical references and index.

Design and implementation of high-throughput screening assays / R. Macarrón and R.P. Hertzberg -- Creation of a small high-throughput screening facility / T. Flak -- Informatics in compound library management / M. Warne and L. Pemberton -- Statistics and decision making in high-throughput screening / I. Coma, J. Herranz and J. Martin -- Enzyme assay design for high-throughput screening / K.P. Williams and J.E. Scott -- Application of fluorescence polarization in HTS assays / X. Huang and A. Aulabaugh -- Screening G protein-coupled receptors: Measurement of intracellular calcium using the fluorometric imaging plate reader / R. Emkey and N.B. Rankl -- High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer / O.J. Trask [and others] -- Recent advances in electrophysiology-based screening technology and the impact upon ion channel discovery research / A. Southan and G. Clark -- Automated patch clamping using the QPatch / K.A. Jones [and others] -- High-throughput screening of the cyclic amp-dependent protein kinase (PKA) using the caliper microfluidic platform / L.J. Blackwell [and others] -- Use of primary human cells in high-throughput screens / A. Dunne, M. Jowett and S. Rees.

Print version record.

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Electronic reproduction. [Place of publication not identified] : HathiTrust Digital Library, 2010. MiAaHDL

Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL

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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL

In the years since the release of the popular first edition, the field of High Throughput Screening (HTS) has evolved considerably, from a small niche area of study to a major, essential scientific technique. In High Throughput Screening: Methods and Protocols, Second Edition, experts in the field fully update the previous edition to best serve as an introduction to HTS for scientists who are just entering the field, and as a provider of key, significant detail so as to be useful to scientists in established HTS operations. Featuring new screening technologies as well as many well established methods, chapters offer comprehensive treatment of the activities directly related to HTS, such as compound library management, data handling, and robotics. As a volume in the highly successful Methods in Molecular Biology™ series, this work provides the kind of meticulous description and implementation advice that is crucial for getting optimal results. Authoritative and intrinsically practical, High Throughput Screening: Methods and Protocols, Second Edition promises to share the highest knowledge and enthusiasm with all those who use this versatile technology in their own labs.

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