System medicine / edited by Ulf Schmitz, Olaf Wolkenhauer.

Includes bibliographical references and index.

Systems medicine : sketching the landscape / Marc Kirschner -- Taking bioinformatics to systems medicine / Antoine H.C. van Kampen and Perry D. Moerland -- Systems medicine : the future of medical genomics, healthcare, and wellness / Mansoor Saqi [and others] -- Next-generation pathology / Peter D. Caie and David J. Harrison -- Training in systems approaches for the next generation of life scientists and medical doctors / Damjana Rozman, Jure Acimovic, and Bernd Schmeck -- Systems medicine in pharmaceutical research and development / Lars Kuepfer and Andreas A. Schuppert -- Systems medicine and infection / Ruth Bowness -- Systems medicine for lung diseases : phenotypes and precision medicine in cancer, infection, and allergy / Bernd Schmeck [and others] -- Third-kind encounters in biomedicine : immunology meets mathematics and informatics to become quantitative and predictive / Martin Eberhardt [and others] -- Systems medicine in oncology : signaling network modeling and new-generation decision-support systems / Silvio Parodi [and others] -- Neurological diseases from a systems medicine point of view / Marek Ostaszewski, Alexander Skupin, and Rudi Balling -- Computational modeling of human metabolism and its application to systems biomedicine / Maike K. Aurich and Ines Thiele -- From systems understanding to personalized medicine : lessons and recommendations based on a multidisciplinary and translational analysis of COPD / Josep Roca [and others] -- RNA systems biology for cancer : from diagnosis to therapy / Raheleh Amirkhah [and others] -- Mathematical models of pluripotent stem cells : at the dawn of predictive regenerative medicine / Pınar Pir and Nicolas Le Novère -- Network-assisted disease classification and biomarker discovery / Sonja Strunz, Olaf Wolkenhauer, and Alberto de la Fuente -- Anatomy and physiology of multiscale modeling and simulation in systems medicine / Alexandru Mizeranschi [and others] -- Mathematical and statistical techniques for systems medicine : the Wnt signaling pathway as a case study / Adam L. MacLean [and others] -- Modeling and simulation tools : from systems biology to systems medicine / Brett G. Olivier, Maciej J. Swat, and Martijn J. Moné.

Online resource; title from PDF title page (springerLink, viewed December 21, 2015).

This volume guides readers through the field of systems medicine by defining the terminology, and describing how established computational methods form bioinformatics and systems biology can be taken forward to an integrative systems medicine approach. Chapters provide an outlook on the role that systems medicine may or should play in various medical fields, and describe different facets of the systems medicine approach in action. Ultimately it introduces tools, resources and methodologies from bioinformatics and systems biology, and how to apply these in a systems medicine project. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, and discuss experimental and computational approaches, methods, and tools that should be considered for a successful systems medicine project. Systems Medicine aims to motivate and provide guidance for collaborations across disciplines to tackle today's challenges related to human health and well-being.