Blood-brain barrier / edited by Tatiana Barichello.

Includes bibliographical references and index.

"This volume focuses on experimental research with applicable models to study physiology, biochemistry, and molecular biology of the blood-brain barrier (BBB). This book is organized into six parts: Part One is an overview of the physiology of BBB; Part Two explores in vitro cell models to study the BBB; Part Three discusses techniques in vivo and ex vivo models to evaluate BBB in Drosophila melanogaster, Zebrafish, and rodents; Part Four looks at permeability, influx, efflux transportation, and drug delivery through the BBB; Part Five talks about various invasive and non-invasive imaging techniques to study BBB; and Part Six describes how molecular biomarkers are used to look at the integrity or dysfunction of the BBB. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory"--Publisher's description

Online resource; title from PDF title page (SpringerLink, viewed December 20, 2018).

Overview of the blood-brain barrier / Tatiana Barichello, Allan Collodel, Rodrigo Hasbun, and Rodrigo Morales -- Methods of delivering molecules through the blood-brain barrier for brain diagnostics and therapeutics / Brian M. Kopec, Kavisha R. Ulapane, Mario E.G. Moral, and Teruna J. Siahaan -- Culturing of rodent brain microvascular endothelial cells for in vitro modeling of the blood-brain barrier / Malgorzata Burek and Carola Y. Fo·rster -- In vitro BBB models: working with static platforms and microfluidic systems / Mohammad A. Kaisar, Vinay V. Abhyankar, and Luca Cucullo -- In vitro cell models of the human blood-brain barrier : demonstrating the beneficial influence of shear stress on brain microvascular endothelial cell phenotype / Keith D. Rochfort and Philip M. Cummins -- Transepithelial/transendothelial electrical resistance (TEER) to measure the integrity of blood-brain barrier / Balaji Srinivasan and Aditya Reddy Kolli

Cell-penetrating peptides as theranostics against impaired blood-brain barrier permeability : implications for pathogenesis and therapeutic treatment of neurodegenerative disease / Swapna Bera and Anirban Bhunia -- Microbial translocation of the blood-brain barrier / Charles T. Spencer and Mireya G. Ramos Muniz -- Transport across the choroid plexus : how to culture choroid plexus cells and establish a functional assay system / Sen Takeda and Keishi Narita -- Drosophila as a model to study the blood-brain barrier / Cameron R. Love and Brigitte Dauwalder -- Zebrafish (Danio rerio) as a viable model to study the blood-brain barrier / Tianzhi Yang and Shuhua Bai -- Evans blue-albumin as a marker to evaluate blood-brain barrier integrity in neonatal and adult rodents / Fabricia Petronilho, Julia L. Goldman, and Tatiana Barichello -- Experimental tools to study the regulation and function of the choroid plexus

Isabel Gonc¸alves, Telma Quintela, Ana Catarina Duarte, Peter Hubbard, Grac¸a Baltazar, Christian Schwerk, Andrea Carmine Belin, Joana Toma´ s, and Cecı´lia Reis A. Santos -- Techniques for evaluating efflux transport of radiolabeled drugs and compounds from the cerebrospinal fluid across the blood-cerebrospinal fluid barrier / Shin-ichi Akanuma, Yoshiyuki Kubo, and Ken-ichi Hosoya -- In vivo analysis to study transport across the blood-retinal barrier / Yoshiyuki Kubo, Shin-ichi Akanuma, and Ken-ichi Hosoya -- Increasing BBB permeability via focused ultrasound : current methods in preclinical research / Dallan McMahon, Charissa Poon, and Kullervo Hynynen -- Evaluation of blood-brain barrier permeability and integrity in juvenile rodents : dynamic contrast-enhanced (DCE), magnetic resonance imaging (MRI), and evans blue extravasation / Trish Domi, Faraz Honarvar, and Andrea Kassner

Recording leukocyte rolling and adhesion on meningeal vessels by intravital microscopy / Aline Silva de Miranda, Thiago Macedo Cordeiro, Milene Alvarenga Rachid, and Antoˆnio Lu´ cio Teixeira -- Molecular imaging of blood-brain barrier permeability in preclinical models using PET and SPECT / Vijayasree V. Giridharan, Tatiana Barichello, and Sudhakar Selvaraj -- Biomarkers for microvascular proteins detection: blood-brain barrier injury and damage measurement / Pavani Sayana, Jean Pierre Oses, Tatiana Barichello, and Vijayasree V. Giridharan.