Amazon cover image
Image from Amazon.com

Meiosis in development and disease / edited by Francesca Cole.

Contributor(s): Material type: TextTextSeries: Current topics in developmental biology ; 151.Publisher: Cambridge, MA : Academic Press, an imprint of Elsevier, 2023Copyright date: ©2023Edition: First editionDescription: 1 online resourceContent type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 0128201622
  • 9780128201626
Subject(s): Additional physical formats: Print version:: No title; Print version:: No titleDDC classification:
  • 571.845 23/eng/20230131
LOC classification:
  • QH605.3 .M45 2023
NLM classification:
  • QU 375
Online resources:
Contents:
Intro -- Meiosis in Development and Disease -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Mechanism of initiation of meiosis in mouse germ cells -- 1. Introduction -- 2. STRA8 plays a key role in the initiation of meiosis -- 3. MEIOSIN interacts with STRA8 during meiotic initiation -- 4. MEIOSIN and STRA8 direct the switch from mitosis to meiosis -- 5. MEIOSIN together with STRA8 determines meiotic entry -- 6. MEIOSIN and STRA8 activate meiotic prophase program -- 7. MEIOSIN and STRA8 boost the transcription of the meiotic genes
8. Sexual difference of meiotic initiation -- 9. Evolutionary conservation and divergence in the meiotic entry system -- 10. Conclusion -- Acknowledgments -- Conflict of interest statement -- References -- Chapter Two: Orchestrating recombination initiation in mice and men -- 1. Introduction-Orchestrating the critical stages of recombination initiation -- 2. Germline replication timing affects broad-scale recombination patterning -- 3. Chromatin loop array formation and loop extrusion -- 4. Creating an accessible local chromatin environment -- 5. Chromatin opening meiosis-specific Pioneer Complex
6. Associate putative hotspot sites in the DNA loops with the chromosomal axis -- 6.1. DSB formation -- 7. Facilitating efficient homology engagement and DSB repair -- 8. PRDM9 redundant meiotic recombination initiation -- 9. Summary -- References -- Chapter Three: Cancer and meiotic gene expression: Two sides of the same coin? -- 1. Introduction -- 1.1. Role of meiotic genes in cancer -- 2. Global DNA demethylation -- 3. Histone modifications -- 4. DNA accessibility -- 5. Higher-order of chromatin structure -- 5.1. Topologically associated domains -- 5.2. Distal regulatory elements
5.3. R-loops -- 6. Conclusions -- Acknowledgments -- Author contributions -- References -- Chapter Four: Phase separation in controlling meiotic chromosome dynamics -- 1. Chromosome dynamics during meiosis -- 2. Phase separation to form biomolecular condensates in cells -- 3. Phase separation in controlling chromatin organization and activities -- 4. Phase separation in meiotic recombination initiation -- 5. Phase separation in homologous chromosome pairing -- 5.1. DSB-independent pairing -- 5.2. DSB-dependent pairing -- 6. Phase separation in synapsis
7. Potential phase separation in mammalian sex body formation -- 8. Perspectives -- Acknowledgments -- References -- Chapter Five: Meiotic chromosome organization and its role in recombination and cancer -- 1. Chromatin and chromosome organization during meiosis -- 2. Evolution of the core axis proteins and the synaptonemal complex -- 3. Morphogenesis and remodeling of the chromosome axis -- 4. Roles of chromosomal axis proteins in DSB and crossover formation during meiosis -- 5. Does the chromosome axis play a role in CO interference?
Holdings
Item type Current library Collection Call number Status Date due Barcode Item holds
eBook eBook e-Library eBook Elsevier Available
Total holds: 0

Intro -- Meiosis in Development and Disease -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Mechanism of initiation of meiosis in mouse germ cells -- 1. Introduction -- 2. STRA8 plays a key role in the initiation of meiosis -- 3. MEIOSIN interacts with STRA8 during meiotic initiation -- 4. MEIOSIN and STRA8 direct the switch from mitosis to meiosis -- 5. MEIOSIN together with STRA8 determines meiotic entry -- 6. MEIOSIN and STRA8 activate meiotic prophase program -- 7. MEIOSIN and STRA8 boost the transcription of the meiotic genes

8. Sexual difference of meiotic initiation -- 9. Evolutionary conservation and divergence in the meiotic entry system -- 10. Conclusion -- Acknowledgments -- Conflict of interest statement -- References -- Chapter Two: Orchestrating recombination initiation in mice and men -- 1. Introduction-Orchestrating the critical stages of recombination initiation -- 2. Germline replication timing affects broad-scale recombination patterning -- 3. Chromatin loop array formation and loop extrusion -- 4. Creating an accessible local chromatin environment -- 5. Chromatin opening meiosis-specific Pioneer Complex

6. Associate putative hotspot sites in the DNA loops with the chromosomal axis -- 6.1. DSB formation -- 7. Facilitating efficient homology engagement and DSB repair -- 8. PRDM9 redundant meiotic recombination initiation -- 9. Summary -- References -- Chapter Three: Cancer and meiotic gene expression: Two sides of the same coin? -- 1. Introduction -- 1.1. Role of meiotic genes in cancer -- 2. Global DNA demethylation -- 3. Histone modifications -- 4. DNA accessibility -- 5. Higher-order of chromatin structure -- 5.1. Topologically associated domains -- 5.2. Distal regulatory elements

5.3. R-loops -- 6. Conclusions -- Acknowledgments -- Author contributions -- References -- Chapter Four: Phase separation in controlling meiotic chromosome dynamics -- 1. Chromosome dynamics during meiosis -- 2. Phase separation to form biomolecular condensates in cells -- 3. Phase separation in controlling chromatin organization and activities -- 4. Phase separation in meiotic recombination initiation -- 5. Phase separation in homologous chromosome pairing -- 5.1. DSB-independent pairing -- 5.2. DSB-dependent pairing -- 6. Phase separation in synapsis

7. Potential phase separation in mammalian sex body formation -- 8. Perspectives -- Acknowledgments -- References -- Chapter Five: Meiotic chromosome organization and its role in recombination and cancer -- 1. Chromatin and chromosome organization during meiosis -- 2. Evolution of the core axis proteins and the synaptonemal complex -- 3. Morphogenesis and remodeling of the chromosome axis -- 4. Roles of chromosomal axis proteins in DSB and crossover formation during meiosis -- 5. Does the chromosome axis play a role in CO interference?

Description based on online resource; title from digital title page (viewed on May 08, 2023).

Powered by Koha